WTSA: 31st Annual Meeting Abstracts: Location as an Important Prognostic Factor for Pulmonary Adenocarcinoma

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31st Annual Meeting Abstracts: Location as an Important Prognostic Factor for Pulmonary Adenocarcinoma

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P14. Location as an Important Prognostic Factor for Pulmonary Adenocarcinoma
A. Ketchedjian¹, B. D. Daly¹, H. C. Fernando¹, L. Florin², C. J. Hunter¹, D. M. Morelli¹, R. J. Shemin¹. ¹Boston Medical Center, Boston, MA, ²Georgetown University, Washington, DC,

Background: Increasing data implicates histologic grade and radiographic appearance along with tumor size as key prognostic indicators for pulmonary adenocarcinoma. This report examines the impact of tumor location (peripheral versus central) on survival.

Methods: Retrospective data on 530 patients with resected pulmonary adenocarcinoma were reviewed. A tumor was considered to be central if it was visualized within the inner third of the lung field or was seen bronchoscopically. Stage and survival were compared between peripheral and central lesions.

Results: Stage is demonstrated in the table.

Location	Stage I	Stage II	Stage IIIA	Stage IIIB	Stage IV
Peripheral	252 (60%)	62 (15%)	65 (16%)	8 (2%)	28 (7%)
Central	27 (23%)	20 (18%)	38 (33%)	11 (10%)	9 (16%)

Central tumors were more advanced and demonstrated a significantly (p = 0.0000) poorer survival (median 18 +/- 2 months) when compared to peripheral tumors (39 +/- 4 months). When adjusted for stage, only stage I tumors demonstrated a significant (p = 0.0248) survival difference favoring peripheral tumors (70 +/-8 months versus 32 +/- 9 months).

Conclusion: Central tumors are more likely to present at later stage. Stage I central tumors carry a poorer prognosis than peripheral stage I cancers. Tumor location should be a factor in determining therapy for stage I adenocarcinomas.

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