|
|
31st Annual Meeting Abstracts: Near-Infrared Spectroscopy Predicts Jugular Venous O2 Saturation but not Cerebral O2 Delivery in an Acute Model of Single Ventricle Physiology
Back to 31st Annual Meeting
Back to Program Outline
6. Near-Infrared Spectroscopy Predicts Jugular Venous O2 Saturation but not Cerebral O2 Delivery in an Acute Model of Single Ventricle Physiology
M. Ricci, P. Lombardi, A. Galindo, E. Coscarella, A. Vasquez, E. Rosenkranz. University of Miami Miller School of Medicine, Miami, FL,
BACKGROUND:
Near-infrared spectroscopy (NIRS) monitors regional cerebral O2 saturation (rSO2). RSO2 parallels jugular-venous O2 saturation (jvSO2), and is used as an indirect indicator of cerebral perfusion. Experience with this technology with single ventricle physiology (SVP) is limited. We tested the hypothesis that rSO2 correlates with jvSO2 in SVP, and established the association between rSO2 and cerebral O2 delivery.
METHODS:
SVP was created in piglets by aorto-pulmonary shunt, echo-guided atrial septostomy, tricuspid valve avulsion, and pulmonary artery occlusion. The INVOS 5100 Cerebral Oxymeter was used to monitor rSO2. Stable-isotope microsphere determination of cerebral blood flow (CBF) was obtained at baseline and with SVP (30min, 120 min, afterload).
RESULTS:
SVP resulted in lower rSO2, CaO2, jvSO2, and cerebral O2 delivery (Figure). Afterload augmentation caused higher rSO2, CaO2, and jvSO2, although cerebral O2 delivery remained unchanged (lower CBF). RSO2 predicted jvSO2, and correlated with arterial O2 saturation and CaO2(Table). No association was found with cerebral O2 delivery.
CONCLUSIONS:
In our study rSO2 predicted jvSO2. As rSO2 is influenced by arterial O2 saturation, lower values should be expected in SVP. The inability of rSO2 to predict cerebral O2 delivery when simultaneous changes in CaO2 are occurring limits its value as an index of adequate CBF. 
Correlation of rSO2 with other variables | Variable | Pearson coefficient | P value | | jv O2 saturation | 0.997 | 0.002 | | arterial O2 saturation | 0.981 | 0.01 | | CaO2 | 0.966 | 0.03 | | extraction ratio | -0.853 | 0.14 | | CBF | -0.778 | 0.22 | | A-V O2 difference | 0.336 | 0.66 | | cerebral O2 delivery | -0.001 | 0.99 |
Back to Program Outline |
